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Diseases associated with nodular pruritus

Diseases associated with nodular pruritus

Prurigo nodularis is often associated with psychological and physical comorbidities. These aspects should be taken into account for successful treatment.

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Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by hyperkeratotic, dome-shaped, intensely itchy papules and nodules that vary in size from a few millimeters to centimeters. PN is associated with chronic comorbidities such as atopic dermatitis, type 2 diabetes, hypertension, chronic kidney disease (CKD), chronic liver disease (CLD), and thyroid disease. Psychological problems also occur frequently, leading to a significant decrease in quality of life.

In a recent retrospective study by Tagdos et al* based on patient files, demographic and clinical characteristics as well as comorbidities of PN subjects were analysed. In addition, the effectiveness of systemic therapies, including methotrexate, cyclosporine, and narrow-band ultraviolet radiation (NB-UVB), was examined in the patients included in the study.

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